-IBIS-1.5.0-

rx

toxidrome

Coumarin toxidrome

botanicals

definition

coumarin toxidrome

the following toxicity information is largely derived from poisonings, overdoses and research on isolated constituents; used with appropriate clinical judgment and cautious prescribing, herbs are safe and efficacious

plants included:

» Anthoxanthum spp.

» Melilotus officinalis

» Ruta graveolens

» Trifolium pratense

» Melilotus officinalis:

treatment of overdose: vitamin K serves as an inhibitor of these antithrombotics and should be administered at least twice daily (Theines and Haley, p. 242)

• coumarin toxidrome: patient experiences internal and external hemorrhagic symptoms including bruising, epistaxis, petechial hemorrhages, subcutaneous swelling, hematemesis, hematochezia, sudden blood effusions in the joints, and neurological changes; long term effects include signs of internal and external blood loss, reduced pulse rate, cardiovascular weakness and death (Theines and Haley, p. 242)

• blood tests may indicate increased prothrombin time; competition with a binding site on albumin possibly intensifies the effects of many medications including antibiotics, salicylates, quinidine, and quinine; renal and hepatic stress can ensue (Theines and Haley, p. 242)

footnotes

Thienes, C.H., Haley, T.J. 1975. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger.

bumin possibly intensifies the effects of many medications including antibiotics, salicylates, quinidine, and quinine; renal and hepatic stress can ensue (Theines and Haley, p. 242)

footnotes

Thienes, C.H., Haley, T.J. 1975. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger.

biger.