-IBIS-1.7.6-
tx
digestive system
liver cancer
Nutrition

dietary guidelines

eating principles:
• fasting is recommended under physician supervision: 7-21 day alkaline fasts

therapeutic foods:
• foods that soothe the Liver, tonify the Liver, invigorate the Qi and Xue (Blood), sour foods

fresh juices:
• carrot (Walker, 145.)
• carrot and spinach (Walker, 145.)
• carrot, beet, and cucumber (Walker, 145.)
• carrot, celery, parsley (Walker, 145.)

recommendations for all cancers:
• seaweeds, mushrooms - Chinese black and Shiitake, figs, beets, beet tops, papaya, mung beans, licorice, sea cucumbers, carrot, garlic, walnut, lychee fruit, mulberries, asparagus, pumpkin, burdock, dandelion greens, white fungus, taro roots, pearl barley, grains, fresh fruits and vegetables (Ni, 108-109.)

specific remedies:
• soup of black or ling zhi mushrooms and white fungus, three times daily. (Ni, 108-109)
• boil together mung beans, pearl barley, adzuki beans, and figs (Ni, 108-109.)
• dandelion, burdock, and chrysanthemum flower tea (Ni, 108-109.)

avoid:
• meat, chicken, cinnamon, anise, pepper, dairy products, spicy foods, high fat foods, smoking, constipation, stress, alcohol, hot sauces, fried foods, salty foods, coffee, caffeine


supplements

Vitamin A
Maitake mushrooms: Research indicates that extracts from the fruiting body of Maitake showed antitumor action against allogenic and syngenic tumors by not only directly activating the various effector cells (macrophages, Natural Killer cells, cytotoxic T cells, etc.) to attack tumor cells, nut also by potentiating the activities of various mediators including lymphokines and IL-1 to enhance cellular immune functions and to prevent a decrease of immune functions in the tumor-bearing host.
(Nanba, H, et al. Chem Pharm Bull 1987,35:1162-1168; Yamada Y, et al. Chemotherapy 1990;38:790-796; Nanba, H. J Naturopathic Med. 1(4):10-15.)
Shark cartilage: 2 g per kg body weight, per day, to inhibit angiogenesis (growth of new blood vessels) in and to tumors. While anecdotal claims of efficacy are widespread no large scale, well-designed clinical research on the efficacy of cartilage for the treatment of cancer have been conducted so no conclusive evidence is available. (Lane WI, 1992.)
Creatinine
Selenium

» drug interactions:
• Vitamins C and E for patients using adriamycin: antioxidants, specifically reduces cardiac toxicity of adriamycin (Doxorubicin)
(Fujita, et al., 1982, 42:309-316; Ellison, 1985; 37 (3): 112-113; Am Heart J, 1986; 111:95.)

» drug interactions:
• Vitamins B1, B2, B3, Vitamin K and folic acid can become deficient in patients using chemotherapy due to consequent anorexia, damage to the digestive tract, and malabsorption (Dreizen, et al., 1990; 87 (1): 163-170.)
Vitamin K has been found to potentiate various chemotherapeutic drugs in animals (Taper, et al, 1987; 40: 575-579.)
Vitamin A and cancer chemotherapy, esp. fluorouracil (5-FU): vitamin A enhances antitumor effect in animals (Nakagawa, et al, 1985; 76: 887-894.)


footnotes

[No authors listed] AE 941--Neovastat. Drugs R D. 1999 Feb;1(2):135-136.

[No authors listed] NCI to sponsor phase III trials of liquid shark cartilage angiogenesis inhibitor. Oncology (Huntingt). 1999 Jan;13(1):82.

Berbari P, Thibodeau A, Germain L, Saint-Cyr M, Gaudreau P, El-Khouri S, Dupont E, Garrel DR. Antiangiogenic effects of the oral administration of liquid cartilage extract in humans. J Surg Res. 1999 Nov;87(1):108-113.

Blackadar CB. Skeptics of oral administration of shark cartilage. J National Cancer Institute 1993 Dec 1;85(23):1961-1962.

D'Amore P, Klagsbrun M. Angiogenesis factors and mechanisms from the pathobiology of neoplasia. Ed. Alphonse E. Sirica. Plenum Pub Corp., 1989, 513-531.

Davis PF, He Y, Furneaux RH, Johnston PS, Ruger BM, Slim GC. Inhibition of angiogenesis by oral ingestion of powdered shark cartilage in a rat model. Microvasc Res. 1997 Sep;54(2):178-182.

Folkman J, Klagsburn M. Angiogenic factors. Science. 1987;235:442-447.

Folkman J, Cotran R. Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol. 1976;16:207-248. (Review)

Folkman J. The vascularization of tumors. Sci Am. 1976 May;234(5):58-64, 70-73.

Horsman MR, Alsner J, Overgaard J. The effect of shark cartilage extracts on the growth and metastatic spread of the SCCVII carcinoma. Acta Oncol 1998;37(5):441-445.
Abstract: This study was designed to investigate the potential of shark cartilage extracts to inhibit the growth and metastatic spread of a murine solid tumour. The SCCVII carcinoma, implanted in the right rear foot of C3H mice, was used. Following tumour implantation, two different commercially available extracts of shark cartilage (Sharkilage and MIA Shark Powder) were dissolved in water and orally administered to the mice at doses that ranged from 5 to 100 mg per mouse. These injections were repeated on a daily basis for up to 25 days post-implantation of the primary tumour. Compared to non-drug-treated animals, daily administration of the shark cartilage extracts did not show any adverse toxicity (as measured by changes in body weight and lethality). More importantly, none of the shark cartilage doses tested had any retarding effect on the growth of the primary tumour, nor did they inhibit the development of metastases seen in the lungs of the tumour-bearing mice at autopsy. In conclusion, our results offer no support for the proposed use of shark cartilage extracts as an anti-cancer therapy.

Hunt TJ, Connelly JF. Shark cartilage for cancer treatment. Am J Health-System Pharm 1995 August 15;52:1756,1760.

Lane AW, Contreras E Jr. High rate of bioactivity (reduction in gross tumor size) observed in advanced cancer patients treated with shark cartilage material. J Naturopathic Med 1992;3:86-88.

Lane IW, Comac L. Sharks Don't Get Cancer: How Sharks Cartilage Could Save Your Life. Avery, 1992.

Lane IW. 60 Minutes. July 11, 1993 transcript.

Langer R, Conn H, Vacanti J, Haudenschild C, Folkman J. Control of tumor growth in animals by infusion of an angiogenesis inhibitor. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4331-4335.
Abstract: Angiogenesis and tumor growth were inhibited in two different animal models by regional infusion of a partially purified cartilage extract. In rabbits bearing corneal implants of V2 carcinoma and receiving the inhibitor, vascular growth rates were < 3% of those in control animals receiving either Ringer's solution or bovine trypsin inhibitor (Trasylol). Subconjunctival B16 melanoma implants in mice receiving the inhibitor weight < 2.5% of implants in mice receiving Ringer's solution, Trasylol, or albumin. Histologic study of major organs and standard blood tests revealed no toxic effects in any of the animals. The inhibitor did not retard the growth of either tumor cell type in tissue culture at concentrations as high as 1 mg/ml. These results suggest that the cartilage factor does not interfere with the growth of the tumor cell population directly but that it prevents tumor growth by inhibiting angiogenesis.

Langer R, Brem H, Falterman K, Klein M, Folkman J. Isolations of a cartilage factor that inhibits tumor neovascularization. Science. 1976 Jul 2;193(4247):70-72.
Abstract: A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.

Lee A, Langer R. Shark cartilage contains inhibitors of tumor angiogenesis. Science 1983 Sep 16;221(4616):1185-1187.
Abstract: Shark cartilage contains a substance that strongly inhibits the growth of new blood vessels toward solid tumors, thereby restricting tumor growth. The abundance of this factor in shark cartilage, in contrast to cartilage from mammalian sources, may make sharks an ideal source of the inhibitor and may help to explain the rarity of neoplasms in these animals.

Mathews J. Media feeds frenzy over shark cartilage as cancer treatment. J National Cancer Institute 1993 Aug 4;85(15):1190-1191.

Mathews J. Sharks still intrigue cancer researchers. J National Cancer Institute 1992 July 1;84(13):1000-1002.

Nanba, H. Activity of Maitake D-fraction to Inhibit Carcinogenisis and Metastasis. Annals of the New York Academy of Sciences. September 30, 1995:243-245.

Nanba, H, Antitumor activity of orally administered D-fraction from Maitake mushroom(Grifola frondosa). J Naturopathic Med. 1(4):10-15.

Nanba, H, Hamaguchi, A, Kuroda, H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987,35:1162-1168.

Nanba, H. Immunostimulant activity in in-vivo and anti-HIV activity in vitro of 3 branched b-1-6-glucans extracted from maitake mushrooms (Grifola frondosa). Abstract, VIII International Conference on AIDS, 1992.

Pan WH, Wang CY, Huang SM, Yeh SY, Lin WG, Lin DI, Liaw YF. Vitamin A, Vitamin E or beta-carotene status and hepatitis B-related hepatocellular carcinoma. Ann Epidemiol 1993 May;3(3):217-224.
Abstract: A case-control study was carried out in 59 patients with newly diagnosed hepatocellular carcinoma and 101 control subjects, who were all male hepatitis B carriers. The odds ratios of hepatocellular carcinoma occurring among hepatitis B carriers in the lowest quartile and those highest quartile of dietary and serum status were 5.3 (1.9 to 15.0) and 86.9 (20.0 to 377.2), respectively. The odds ratios for hepatitis B carriers in the lowest quartile and those in the highest quartile of dietary and serum beta-carotene status were 1.7 (0.7 to 4.1) and 5.0 (1.9 to 13.2). Vitamin E status did not differ in case patients and control subjects. Low education level, heavy consumption of alcohol, and smoking status were also associated with increased odds of hepatocellular carcinoma. Serum retinol, positively associated with dietary retinol, demonstrated an independent effect on hepatocellular carcinoma. This effect may reflect changes in the physiologic condition of the patients at the time of entering the hospital.

Yamada, Y, Nanba, H, Kuroda, H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790-796.

See also Sources file