-IBIS-1.5.0-
rx
toxidrome
Cinchona toxidrome
botanicals
definition
cinchona toxidrome
the following toxicity information is largely derived from poisonings, overdoses and research on isolated constituents; used with appropriate clinical judgment and cautious prescribing, herbs are safe and efficacious
plants included:
» Cinchona spp.
systemic problems include confusion, excitement and restlessness, followed by weakness, hypotension, cardiac irregularities, convulsions, tinnitus, and blurred vision; as respirations become slow and labored, patient may lose sight and hearing; death is due to cardiac arrest and respiratory failure (Dreisbach, pp. 405, 410; Ellingwood, pp. 171 - 175)
Cinchonism: headache, chills, fever, paroxysms, diaphoresis, gastric irritation, nausea and diarrhea, vertigo, ataxia, delirium, feeble circulation and an imperceptible pulse, severe cardiac changes; deafness may occur. Chronic intake may also cause a number of ocular effects including dilated pupils, visual loss, pallor of the optic discs, retinal vasoconstriction, papilledema; later, visual fields may be diminished. There is a potential for liver and kidney problems (Dreisbach, pp. 405, 410; Ellingwood, pp. 171 - 175)
laboratory test results: eosinophilia, thrombocytopenia, shadow cells; hematuria, albuminuria, urobilinuria, urobilinogenuria, bilirubinuria (von Oettingen, pp. 124 - 134); may cause hemolytic anemia or aplastic anemia
potential teratogen (Keeler and Tu, p. 172)
footnotes