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AIDS/HIV Naturopathic Treatment
Opportunistic infection prophylaxis and treatment
Integrative Therapies
definition
Treatment Principle #7.
Opportunistic infection prophylaxis and treatment: viral/bacterial/protozoal/yeast
Bacterial infections
Zinc -
Hypozincemia in 228 HIV+ patients was associated with an increased incidence of concomitant systemic bacterial infections, but not PCP, viral, or fungal infections. 206
CMV, Candida, Cryptococcus, Herpes, Mycobacteria, Mycoplasma, Tuberculosis,
Garlic -- 4 caps/day
Antiviral activity of the extract against CMV 207
Effective against Herpes virus, cryptococcal, mycobacterial, and candidal
organisms 208, 209, 210, 211, 212, 213.
Enhances natural killer cell activity in AIDS patients 214
Colloidal Silver (concentration of 3 ppm) -- 1 tsp twice daily
Electrochemical Ag + solutions exhibit antimicrobial effectiveness against E. Coli, P. Aeruginosa, C. Albicans and A. Niger 215
SSKI (Super Saturated Potassium Iodide) -- 8 gtt/day
Vit D3 -- supplements not recommended for most patients, unless they have TB, MAI or psoriasis (Exposure of skin to sunlight produces Vit D, and in moderation, is a healthy source).
Vit D has been shown to be useful in treating/preventing Tuberculosis, but too much can compromise the B & T Lymphocyte efficiency. 216
AIDS patients with Mycobacterium avium complex infection had severely decreased serum vit D. 217.
The hormonal form of vitamin D, 1,25(OH)2D3, is involved in the regulation of the immune system. 218.
HIV-related Psoriasis responded to a topical vitamin D analogue. 219
Fungal infections: Thuja (Cedar), Te Tree oil, Calendual ointment applied locally;
Kaposi's sarcoma
Unsaturated fatty acids (see also section 3b, 5)
Extract of Chelidonium majus, 10 mg IV every other day for 10 injections, made KS lesions diminish in size, thickness, and color, and no new lesions were noted. Experimental group did significantly better compared to controls. 220
Essential fatty acids formulated to increase the tissue levels of dihomo gamma linolenic acid (DGLA) relative to arachidonic acid (AA) cause a regression in early Kaposi's sarcoma. Int Conf AIDS, 1989 Jun 4-9, 5:, 479 (abstract no. Th.B.P.381)
Vitamin A may be useful in treating KS (Standish, personal communication).
Parasites --
Pancreatin -- (1400 mg), 2 tablets after meals, if CDSA is abnormal
Artemesia (Worm wood) has been anecdotally reported to be useful in treating GI parasites
Pneumocystis carinii pneumonia
Gingko -- 2 caps twice daily-tid
The extract has a slightly anti-inflammatory effect 221
Ginkgo increases cerebral blood flow in 70% of patients evaluated 222
Shows in vitro and in vivo activity against Pneumocystis carinii 223
Zinc
Zinc was found to be effective treatment in 12 patients for infections due to Pneumocystis carinii and Candida, but not for cytomegalovirus and toxoplasma infections. 224
Crytosporidiosis
Hyperimmune bovine colostrum
Hoerr and Bostwick at Galagen, the Research division of Land o Lakes, has developed a treatment for AIDS-related cryptosporidial diarrhea. Colostrum from cows immunized against cyptosporidium is lyophilized and given orally in 10 gram doses reconstituted in water four times a day. Bastyr University and the University Health Clinic (Standish as clinical investigator) have been two of the national clinical sites evaluating the efficacy of hyperimmune bovine colostrum (Sporidin-G) in cryptosporidial diarrhea. In six patients treated for 20 -40 days, four had resolution of diarrhea and elimination of detectable cryptosporidium oocysts in follow-up stool samples.
footnotes
HIV/AIDS: Naturopathic Medical Principles and Practice. Standish, Leanna J., Ruhland, John F., DiDomenico, Beth, and Kjersten Gmeiner. Bastyr University AIDS Research Center. November, 1997.
Bastyr Footnotes:
206. Koch J, Neal EA, Schlott MJ, Garcia-Shelton YL, Chan MF, Weaver KE, Cello JP: Zinc levels and infections in hospitalized patients with AIDS. Nutrition 12:515-8, 1996
207. Guo NL, Lu DP, Woods GL, Reed E, Zhou GZ, Zhang LB, Waldman RH: Demonstration of the anti-viral activity of garlic extract against human cytomegalovirus in vitro. Chin Med J (Engl) 106:93-6, 1993
208. Tariq H, et al.: J Nat'l Med Assoc 80:439, 1988
209. Frontling RA, Blumer GS: In vitro effect of aqeous extract of garlic on the growth and viability of cryptococcus neoforms. Mycopatholgia 70:397-405, 1978
210. China HMCo: Garlic in cryptococcal meningitus; a preliminary report of 21 cases. Chin Med J 93:123, 1980
211. Tsai Y, et al.: Antiviral properties of garlic: In vitro effects on influenzaB, herpes simplex 1, and coxsackie viruses. Planta Medica 27:460-1, 1985
212. Delaha EC, Gargusi VL: Inhibition of mycobactyeria by garlic extract (allium sativum). Antimicrob Agents Chemother 27:485-6, 1985
213. Rao RR, et al.: Inhibition of Mycobacterium tuberculosis by garlic extract. Nature 157, 1946
214. Abdullah TH, et al.: Enhancement of natural killer cell activity in AIDS with garlic. Deutsche Zeit Onk 21:52, 1989
215. Simonetti N, Simonetti G, Bougnol F, Scalzo M: Electrochemical Ag+ for preservative use. Appl Environ Microbiol 58:3834-6, 1992
216. Lochner JD, Schneider DJ: The relationship between tuberculosis, vitamin D, potassium and AIDS. A message for South Africa? S Afr Med J 84:79-82, 1994
217. Haug CJ, Aukrust P, Lien E, Muller F, Espevik T, Froland SS: Disseminated Mycobacterium avium complex infection in AIDS: immunopathogenic significance of an activated tumor necrosis factor system and depressed serum levels of 1,25 dihydroxyvitamin D. J Infect Dis 173:259-62, 1996
218. Thomasset M: Vitamin D and the immune system. Pathol Biol (Paris) 42:163-72, 1994
219. Gray JD, Bottomley W, Layton AM, Cotterill JA, Monteiro E: The use of calcipotriol in HIV-related psoriasis. Clin Exp Dermatol 17:342-3, 1992
220. Martinez G, et al.: effect of the alkaloid derivative Ukrain in AIDS patients with Kaposi's Sarcoma. Int Con AIDS 9:401, 1993
221. Herz W: Experimental pharmacology of ginkgo-biloba. Minerva Med 64:4160-6, 1973
222. Agnoli A, Fiorani P, Pistolese GR: Preliminary results in the modifications of cerebral blood flow using xenon-133 during administration of ginkgo-biloba. Minerva Med 64:4166-73, 1973
223. Atzori C, Bruno A, Chichino G, Bombardelli E, Scaglia M, Ghione M: Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii. Antimicrob Agents Chemother 37:1492-6, 1993
224. Mocchegiani E, Fabris N: Age-related thymus involution: zinc reverses in vitro the thymulin secretion defect. Int J Immunopharmacol 17:745-9, 1995
Special Thanks to Leanna Standish, N.D., Ph.D and the staff of the Bastyr University AIDS Research Center.
Reprinted with permission from Pizzorno J, Murray M, The Textbook of Natural Medicine. Revised Edition. London/New York: Churchill-Livingston, 1999.