-IBIS-1.5.0-
tx
digestive system
hyperchlorhydria
diagnoses

definition and etiology

definition:
hypersecretion of hydrochloric acid in the stomach

etiology:
The causes include physical or mental/emotional stress, caffeine (coffee, chocolate, cocoa, black tea), hypoglycemia, and Zollinger-Ellison syndrome (gastrin-secreting pancreatic tumor)

signs and symptoms

signs and symptoms:
• heartburn
• peptic ulcer disease
• gastritis

lab findings:
• (+) Heidelberg pH capsule analysis for acidity
• increased serum gastrin (with Z-E disease)
• (+) endoscopy for ulceration (possibly)
• (+) for hypoglycemia (possibly)

course and prognosis

Zollinger-Ellison syndrome is a serious disease that requires careful treatment and close follow-ups. 60% of the pancreatic tumors are malignant.

In other causes of hyperchlorhydria, peptic ulcers may occur if the hyperchlorhydria is left untreated, and gastritis may develop and become chronic.

differential diagnosis

Hypergastrinemia can be found in:
• pernicious anemia
• renal insufficiency
• chronic gastritis
• pheochromocytoma
• marked intestinal resection

Also need to differentiate:
• esophagitis
• hiatal hernia
• gastroesophageal reflux
• peptic ulcer disease


footnotes