-IBIS-1.5.0-
rx
toxidrome
Coumarin toxidrome
botanicals
definition
coumarin toxidrome
the following toxicity information is largely derived from poisonings, overdoses and research on isolated constituents; used with appropriate clinical judgment and cautious prescribing, herbs are safe and efficacious
plants included:
» Anthoxanthum spp.
» Melilotus officinalis
» Ruta graveolens
» Trifolium pratense
» Melilotus officinalis:
treatment of overdose: vitamin K serves as an inhibitor of these antithrombotics and should be administered at least twice daily (Theines and Haley, p. 242)
coumarin toxidrome: patient experiences internal and external hemorrhagic symptoms including bruising, epistaxis, petechial hemorrhages, subcutaneous swelling, hematemesis, hematochezia, sudden blood effusions in the joints, and neurological changes; long term effects include signs of internal and external blood loss, reduced pulse rate, cardiovascular weakness and death (Theines and Haley, p. 242)
blood tests may indicate increased prothrombin time; competition with a binding site on albumin possibly intensifies the effects of many medications including antibiotics, salicylates, quinidine, and quinine; renal and hepatic stress can ensue (Theines and Haley, p. 242)
footnotes
Thienes, C.H., Haley, T.J. 1975. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger.