-IBIS-1.5.0-
rx
Misc. Lab Diagnostics
vitamin B12 Deficiency (Schilling Test)
diagnoses
definition
Schilling Test: vitamin B12:
used to assess cause of B12 deficiency.
1) Ingest 1 mcg radioactive B12 without intrinsic factor. Next give a large "flushing" dose of non-labeled B12 via IM and collect 24-48 hour urine.
» If find greater than 7% *B12 in urine = normal
» If find less than 7% *B-12 in urine = deficient B12 because of "malabsorption" or "lack of IF"
2) Ingest radioactive B12 with IF and find *B12 in urine = pernicious anemia
3) Ingest radioactive B12 with IF and find no *B12 in the urine = malabsorption
note: 50% -75% of patients with pernicious anemia have antibodies to IF.
(Marz)
footnotes